Lactic acid
has a bad reputation. Many
people blame it for fatigue, sore muscles,
and cramps. They think of it as a waste
product that should be avoided at all cost.
Guess what? Scientists have discovered that
lactic acid plays a critical role in
generating energy during exercise. Far
from being the bad boy of metabolism, lactic
acid provides fuels for many tissues, helps
use dietary carbohydrates, and serves as
fuel for liver production of glucose and
glycogen. In fact, lactic
acid is nature's way of helping you survive
stressful situations.
Lactic acid
has a dark side. When your body makes lactic
acid, it splits into lactate ion (lactate)
and hydrogen ion. Hydrogen ion is the acid
in lactic acid. It interferes with
electrical signals in your muscles and
nerves, slows energy reactions, and impairs
muscle contractions. The burn you feel in
intense exercise is caused by hydrogen ion
buildup. So, when you fatigue, don't blame
it on lactic acid. Rather, place the blame
where it belongs- on hydrogen ion.
Lactate has
been made guilty by association. Far from
being a metabolic pariah, the body loves
lactate. It is an extremely fast fuel that's
preferred by the heart and muscles during
exercise. Lactate is vital for ensuring that
your body gets a steady supply of
carbohydrates, even during exercise that
lasts for many hours. Lactate is so
valuable, that taking it as part of a fluid
replacement drink before, during, or after
exercise improves performance and speeds
recovery.
Lactate is a
friend to triathletes, distance runners,
swimmers, and cyclists. When you learn the
facts about lactic acid, you will think of
it in a whole new light. Harness the power
of lactic acid and you will increase your
energy level and stave off fatigue.
Here are ten
things you should know about lactic acid:
-
Lactic
acid is formed from the breakdown of
glucose.
During this process the cells make ATP
(adenosine triphosphate), which provides
energy for most of the chemical
reactions in the body. Lactic acid
formation doesn't use oxygen, so the
process is often called anaerobic
metabolism. Lactate-related ATP
production is small but very fast. This
makes it ideal for satisfying energy
needs anytime exercise intensity exceeds
50% of maximum capacity.
-
Lactic
acid doesn't cause muscle soreness and
cramps.
Delayed onset muscle soreness, the achy
sensation in your muscles the day after
a tough workout, is caused by muscle
damage and post-exercise tissue
inflammation. Most muscle cramps are
caused by muscle nervous receptors that
become over-excitable with muscle
fatigue.
Many
athletes use massage, hot baths, and
relaxation techniques to help them rid
their muscles of lactic acid and thus
relieve muscle soreness and cramping.
While these techniques probably have
other benefits, getting rid of lactic
acid isn't one of them. Lactate is used
rapidly for fuel during exercise and
recovery and doesn't remain in the
muscles like motor oil.
-
The body
produces lactic acid whenever it breaks
down carbohydrates for energy.
The faster you break down glucose and
glycogen the greater the formation of
lactic acid. At rest and submaximal
exercise, the body relies mainly on fats
for fuel. However, when you reach 50% of
maximum capacity, the threshold
intensity for most recreational exercise
programs, the body "crosses over" and
used increasingly more carbohydrates to
fuel exercise. The more you use
carbohydrates as fuel, the more lactic
acid you produce.
-
Lactic
acid can be formed in muscles that are
receiving enough oxygen.
As you increase the intensity of
exercise, you rely more and more on
fast-twitch muscle fibers. These fibers
use mainly carbohydrates to fuel their
contractions. As discussed, whenever you
break down carbohydrates for energy,
your muscles produce lactic acid. The
faster you go, the more fast-twitch
muscles you use. Consequently, you use
more carbohydrates as fuel and produce
more lactic acid. Increased blood lactic
acid means only that the rate of entry
of lactic acid into the blood exceeds
the removal rate. Oxygen has little to
do with it.
-
Many
tissues, particularly skeletal muscles,
continuously produce and use lactic
acid.
Blood levels of lactic acid reflect the
balance between lactic acid production
and use. An increase in lactic acid
concentration does not necessarily mean
that the lactic acid production rate was
increased. Lactic acid may increase
because of a decreased rate of removal
from blood or tissues.
Lactic
acid production is proportional to the
amount of carbohydrates broken down for
energy in the tissues. Whenever you use
carbohydrates, a significant portion is
converted to lactate. This lactate is
then used in the same tissues as fuel,
or it is transported to other tissues
via the blood stream and used for
energy. Rapid use of carbohydrate for
fuel, such as during intense exercise,
accelerates lactic acid produciton.
Temporarily, lactic acid builds up in
your muscles and blood because it can't
be used as fuel fast enough. However, if
you slow down the pace of exercise or
stop exercising, the rate of lactate
used for energy soon catches up with the
rate of lactate production.
Dr. George
Brooks, a Professor from the Department
of Integrative Biology at University of
California at Berkeley, described the
dynamic production and use of lactic
acid in metabolism in his "Lactate
Shuttle Theory." This theory describes
the central role of lactic acid in
carbohydrate metabolism and it's
importance as a fuel for metabolism.
-
The body
uses lactic acid as a biochemical
"middleman" for metabolizing
carbohydrates.
Carbohydrates in the diet are digested
and enter the circulation form the
intestines to the liver mainly in the
form of glucose (blood sugar). However,
instead of entering the liver as glucose
and being converted directly to
glycogen, most glucose from dietary
carbohydrate bypasses the liver, enters
the general circulation and reaches your
muscles and converts into lactic acid.
Lactic acid then goes back into the
blood and travels back to the liver
where it is used as building blocks for
making liver glycogen. Your body
produces much of its liver glycogen
indirectly from lactic acid rather than
directly from blood glucose.
Scientists
call the process of making liver
glycogen from lactic acid the "Glucose
Paradox". The theory was formulated by
famous biochemist Dr. J.D. McGarry and
his associates. It shows the importance
of lactic acid in carbohydrate
metabolism.
-
During
endurance races, such as marathons and
triathlons, blood lactic acid levels
stabilize even though lactic acid
production increases. This occurs
because your capacity to produce lactic
acid is matched by your ability to use
it as fuel. Early during a race, there
is a tremendous increase in the rates
that muscle uptake and use glucose and
breakdown glycogen. The increased rate
of carbohydrate metabolism steps up
production of muscle lactic acid, which
also causes an increase in blood lactic
acid.
As your
body directs blood to your working
muscles, you can shuttle the lactate to
other tissues and use it as fuel. This
reduces lactic acid levels in your
muscles and blood, even though you
continue to produce great quantities of
lactic acid. However, you often feel
better during the race or training. This
relief is sometimes called "second
wind".
Scientists
use radioactive tracers to follow the
use pattern of fuels in your blood and
muscles. Their studies show that during
exercise, lactic acid production and
removal continue at 300-500 percent of
resting rates, even though oxygen
consumption has stabilized at submaximal
levels.
-
The heart,
slow-twitch muscle fibers, and breathing
muscles prefer lactate as a fuel during
exercise. In the heart, for
example, the uptake of lactate increases
many fold as the intensity of exercise
increases while uptake of glucose
remains unchanged. These
tissues suck up lactate at a fast rate
to satisfy their energy needs.
-
Lactic
acid is a very fast fuel that can be
used to athletes' advantage during
exercise.
The concentration of both glucose and
lactic acid rise in the blood after a
carbohydrate-rich meal, but the blood
lactic acid concentration does not rise
much because it is removed so rapidly.
The body converts glucose, a substance
removed from the blood only sluggishly,
to lactate, a substance removed and used
rapidly. Using lactic acid as a
carbohydrate "middleman" helps you get
rid of carbohydrates from your diet,
without increasing insulin or
stimulating fat synthesis. During
exercise, you won't want an increase in
insulin because it decreases the
availability of carbohydrates that are
vital to high performance metabolism.
Why is
lactic acid so important in metabolic
regulation? The exact answer is unknown,
but there do appear to be several
physiological reasons. Lactic acid- in
contrast to glucose and other fuels- is
smaller and better exchanged between
tissues. It moves across cell membranes
by a rapid process called facilitated
transport. Other fuels need slower
carrier systems such as insulin. Also,
lactate is made rapidly in large
quantities in muscle and released into
general circulation. Muscle cells with
large glycogen reserves cannot release
significant amounts of this potential
energy source as glucose because muscle
lacks a key enzyme required to produce
free glucose that can be released to the
blood.
Including
lactate as part of a fluid replacement
beverage provides a rapid fuel that can
help provide energy during intense
exercise. The rationale for including
lactate in athletic drinks is simple-
since the body breaks down so much of
dietary carbohydrates to lactate anyway,
why not start with lactate in the first
place? Lactate in the drink can be used
rapidly by most tissues in the body and
serves as readily available building
blocks for restoring liver glycogen
during recovery.
-
Proper
training programs can speed lactic acid
removal from your muscles.
This can be achieved by combining high
intensity, interval, and over-distance
training. Athletes and coaches must
learn to deal effectively with lactic
acid. Fortunately, most training
programs incorporate elements necessary
to speed lactate removal. Training
programs should build your capacity to
remove lactic acid during competition.
Lactic
acid formation and removal rates
increase as you run, bike or swim
faster. To improve your capacity to use
lactate as a fuel during exercise, you
must increase the lactic acid load very
high during training. Training with a
lot of lactic acid in your system
stimulates your body to produce enzymes
that speed the use of lactic acid as a
fuel.
High
intensity interval training will cause
cardiovascular adaptations that increase
oxygen delivery to your muscles and
tissues. Consequently, you have less
need to breakdown carbohydrate to lactic
acid. Also, better circulation helps
speed the transport of lactic acid to
tissues that can remove it from the
blood.
Over
distance training causes muscular
adaptations that speed the rate of
lactate removal. Over distance training
in running, swimming, or cycling
increases muscle blood supply and the
mitochondrial capacity. Mitochondria are
structures within the cells that process
fuels, consume oxygen, and produce large
amounts of ATP. A larger muscle
mitochondrial capacity increases the use
of fatty acids as fuel, which decreases
lactate formation and speeds its
removal.
Nutrition is
also important, strenuous training depletes
glycogen reserves in the muscle and liver. A
diet high in carbohydrates is essential for
all endurance athletes. Carbohydrates supply
an immediate source of glucose so the
athlete has a feeling of well-being and a
source of quick energy. Further, glucose is
used to restore muscle glycogen from
exercise. When the blood glucose and muscle
glycogen reserves are renewed, glucose
provides a source of lactate that helps
replenish liver glycogen.
Summary
Lactic acid is
an important fuel for the body during rest
and exercise. It is used to synthesize liver
glycogen and is one of our most important
energy sources. Lactate is the preferred
fuel source in highly oxidative tissues,
such as heart muscle and slow-twitch
skeletal muscle fibers. It is used rapidly
by the body and is a valuable component in
athletic fluid replacement beverages.
Lactic acid
also is a powerful organic acid, and its
accumulation can cause distress and fatigue
during exercise. Athletes need both high
intensity and over-distance training to
improve the capacity to use lactic acid as a
fuel during exercise and recovery. High
intensity training develops cardiovascular
capacity that reduces lactic acid transport
to tissues that can use it as fuels. Over
distance training causes tissue enzymes
adaptations that increase use of fatty acids
for energy. This helps slow lactic acid
production from carbohydrates and to enhance
tissues ability to use lactic acid as fuel.
References
Ahlborg G.,
Felig P. Lactate and glucose exchange across
the forearm, legs and splanchnic bed during
and after prolonged leg exercise. J. Clin.
Invest. 69: 45-54. 1982.
Ahlborg G.,
Wahren J., Felig R. Splanchnic and
peripheral glucose and lactate metabolism
during and after prolonged arm exercise. J.
Clin. Invest. 77: 690-699, 1986.
Brooks G.A.,
Fahey T.D., White T. Exercise Physiology:
Human Bioenergetics and Its Applications.
Mt. View, CA: Mayfield Publishing Co., 1985.
Brooks, G.A.
Lactate production under fully aerobic
conditions. The lactate shuttle during rest
and exercise. Fed. Proc. 45: 2924-2929,
1986.
Brooks, G.A.
Mammalian fuel utilization during sustained
exercise. Comp. Biochem. Physiol. 120:
89-107, 1998.
Brooks, G.A.,
Mercier J. The balance of carbohydrate and
lipid utilization during exercise: the
crossover concept (brief review). J. Appl.
Physiol. 80: 2253-2261, 1994.
Brooks, G.A.
and Trimmer J.K. Glucose kinetics during
high-intensity exercise and the crossover
concept. J. Appl. Physiol. 80: 1073-1074,
1996.
Donovan C.M.,
Brooks G.A. Endurance training affects
lactate clearance, not lactate production.
Am. J. Physiol. 244: E83-E92, 1983.
Hultman E.A.
Fuel selection muscle fiber. Proc. Nutr.
Soc. 54: 107-121, 1995.
Zinker
B.A., Wilson R.D., Wasserman D.H.
Interaction of decreased arterial PO2 and
exercise on carbohydrate metabolism in the
dog. Am. J. Physiol. 269: E409-E417, 1995 |